Malic acid is effective for treating xerostomia caused by oral GVHD, but not for skin repair, and study designs are heterogeneous.
仅涉及作用机制3 篇
由MS低共熔溶剂形成的自组装凝胶微针作为经皮递送系统用于色素沉着过度治疗
结论解读 · 中文
苹果酸-山梨醇DES凝胶微针负载姜黄素用于治疗色素沉着，苹果酸作为溶剂成分，非单独测试修护功效。
结论解读 · EN
Malic acid-sorbitol DES gel microneedle loaded with curcumin for treating hyperpigmentation, malic acid as solvent component, not tested alone for repair efficacy.
Malic acid-glycerol NaDES extract shows anti-tyrosinase, anti-hyaluronidase, and anti-collagenase activities, but malic acid is a solvent component, not tested alone, and repair efficacy was not directly tested.
α-羟基酸对皮肤的双重作用
结论解读 · 中文
综述讨论了AHAs（含苹果酸）对皮肤光损伤的影响不确定，仅提及机制，未明确支持修护功效。
结论解读 · EN
The review discusses the uncertain effects of AHAs (including malic acid) on skin photodamage, only mentions mechanisms, without clearly supporting repair efficacy.
未提供数据3 篇
在3D重建人表皮模型KeraSkin™中评估清洁剂常用酸的皮肤刺激性
结论解读 · 中文
苹果酸在0.1M时未引起皮肤刺激，在1M时被判定为刺激物，不支持修护功效。
结论解读 · EN
Malic acid at 0.1M did not cause skin irritation, but at 1M was judged as irritant, not supporting repair efficacy.
苹果酸触发人表皮角质形成细胞凋亡：内质网应激和线粒体依赖性信号通路的参与
结论解读 · 中文
苹果酸诱导角质形成细胞凋亡和抗增殖，不支持修护功效。
结论解读 · EN
Malic acid induces apoptosis and anti-proliferation in keratinocytes, not supporting repair efficacy.
使用体外静态扩散池模型评估冲洗型个人护理产品中微量α-羟基酸在人皮肤中的可忽略渗透
结论解读 · 中文
苹果酸在冲洗型产品中皮肤渗透可忽略，但未测试修护功效，且高浓度AHA可能增加光损伤。
结论解读 · EN
Malic acid shows negligible skin penetration in rinse-off products, but repair efficacy was not tested, and high-concentration AHA may increase photodamage.