褐藻糖胶 × 舒缓

HAZ@Fu NPs通过PI3K-Akt通路促进M2巨噬细胞极化，减轻炎症，促进伤口愈合。

HAZ@Fu NPs promoted M2 macrophage polarization via PI3K-Akt pathway, mitigating inflammation and promoting wound healing.

Gel&Fuc-TA水凝胶通过调节巨噬细胞向M2表型转化，减少IL-6、IL-1β、TNF-α，增加IL-10，表现出抗炎作用。

Gel&Fuc-TA hydrogel showed anti-inflammatory effects by regulating macrophage polarization to M2 phenotype, reducing IL-6, IL-1β, TNF-α, and increasing IL-10.

岩藻聚糖乳膏剂量依赖性抑制角叉菜胶诱导的水肿并改善机械性异常性疼痛，抗炎效果与双氯芬酸凝胶相当。

Fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia, with efficacy comparable to diclofenac gel.

LJSF4在LPS诱导的RAW264.7细胞和斑马鱼中均表现出抗炎作用，减少NO和细胞因子产生，并下调MAPK和NF-κB通路。

LJSF4 showed anti-inflammatory effects in LPS-induced RAW264.7 cells and zebrafish, reducing NO and cytokine production, and downregulating MAPK and NF-κB pathways.

LMF抑制UVB诱导的炎症，减少IL-1β释放，增加IL-10，并抑制MMP表达，具有抗炎作用。

LMF inhibited UVB-induced inflammation, reduced IL-1β release, increased IL-10, and suppressed MMP expression, showing anti-inflammatory effects.

SCFC4抑制UVB诱导的炎症反应上游介质，通过抑制NF-κB和MAPK通路，激活Nrf2通路，具有抗炎作用。

SCFC4 suppressed upstream mediators of UVB-induced inflammatory responses by inhibiting NF-κB and MAPK pathways and activating Nrf2 pathway, showing anti-inflammatory effects.

岩藻聚糖/壳聚糖纳米粒负载甲氨蝶呤后减少促炎细胞因子，但岩藻聚糖本身作为载体，抗炎作用主要归因于甲氨蝶呤，而非岩藻聚糖单独。

Fucoidan/chitosan nanoparticles loaded with methotrexate reduced pro-inflammatory cytokines, but the anti-inflammatory effect is mainly attributed to methotrexate, not fucoidan alone.