尿刊酸

研究未发现尿刊酸水平影响皮肤免疫反应，且未涉及皮肤刺激风险，因此不证实该成分存在皮肤刺激风险。

The study found no effect of urocanic acid levels on cutaneous immune reactivity and did not address skin irritation, thus not supporting the risk.

研究显示顺式尿刊酸减轻炎症和红斑，未引起刺激，反而具有抗炎作用，因此不证实皮肤刺激风险。

The study shows cis-UCA reduces inflammation and erythema without causing irritation, indicating no skin irritation risk.

该研究显示顺式尿刊酸在100 μg/ml浓度下对人RPE细胞耐受良好，且具有保护作用，未报告刺激风险。

The study shows cis-urocanic acid is well tolerated at 100 μg/ml in human RPE cells and has protective effects, with no irritation risk reported.

该研究显示顺式尿刊酸耐受良好，并抑制过敏反应，未报告刺激作用，反而具有抗过敏效果。

The study shows cis-urocanic acid is well tolerated and inhibits allergic responses, with no irritation reported; it has anti-allergic effects.

临床研究显示0.5%和2.5%顺式尿刊酸滴眼液总体安全，但62.2%受试者出现轻度短暂眼刺激，表明存在轻度刺激风险。

Clinical study shows 0.5% and 2.5% cis-urocanic acid eye drops are generally safe, but 62.2% subjects experienced mild transient eye irritation, indicating mild irritation risk.

该研究未评估尿刊酸的眼刺激风险，而是研究其抑制UV-B诱导的炎症和凋亡，未提及刺激作用。

The study does not assess eye irritation risk of urocanic acid; it focuses on its inhibition of UV-B-induced inflammation and apoptosis, with no mention of irritation.

该研究显示顺式尿刊酸在100 μg/ml浓度下对未照射细胞无毒性，且抑制UV-B诱导的炎症和细胞损伤，高浓度5000 μg/ml才有毒性，未证实其作为成分具有眼刺激风险。

The study shows cis-urocanic acid is non-toxic to non-irradiated cells at 100 μg/ml and suppresses UV-B-induced inflammation and cytotoxicity; toxicity only at 5000 μg/ml, so it does not confirm eye irritation risk.

该综述提到5%顺式尿刊酸乳膏对特应性皮炎有效，表明其可能具有治疗作用而非致敏风险。

The review mentions that 5% cis-urocanic acid emulsion cream was effective in treating atopic dermatitis, suggesting a therapeutic effect rather than a sensitization risk.

该研究将顺式尿刊酸作为免疫抑制剂使用，而非作为致敏原，因此未证实其致敏风险。

The study used cis-urocanic acid as an immunosuppressant, not as a sensitizer, thus not supporting a sensitization risk.

该研究未发现尿刊酸异构体对树突状细胞迁移有显著影响，因此未证实其致敏风险。

The study found no significant effect of UCA isomers on dendritic cell migration, thus not supporting a sensitization risk.

顺式尿刊酸在100 μg/ml浓度下保护ARPE-19细胞免受UVB诱导的光毒性，表明其无光毒性反而有保护作用。

Cis-UCA at 100 μg/ml protected ARPE-19 cells from UVB-induced phototoxicity, indicating no phototoxicity but rather protection.

儿童和成人中总尿刊酸浓度与MED均无相关性，表明尿刊酸不增加光毒性。

Total UCA concentration did not correlate with MED in children or adults, indicating UCA does not increase phototoxicity.

该研究未发现总尿刊酸浓度与最小红斑量（MED）相关，表明尿刊酸不增加光毒性。

The study found no correlation between total UCA concentration and MED, indicating UCA does not increase phototoxicity.