透明质酸钠

含透明质酸钠的微针处理组小鼠无红斑和水肿，针孔5分钟内完全消失，表明透明质酸钠无刺激且具修复功能

Mice treated with sodium hyaluronate microneedles showed no erythema or edema, pinholes disappeared within 5 min, indicating no irritation and skin repair

含透明质酸钠的微乳凝胶显示可忽略的皮肤刺激，表明透明质酸钠安全

Sodium hyaluronate-containing microemulsion gel showed negligible skin irritation, indicating safety

观察4天，两种配方均未出现水肿或红斑等刺激迹象，证实透明质酸钠作为赋形剂无皮肤刺激

No signs of irritation (edema, redness) observed after 4 days for both formulations, confirming sodium hyaluronate as excipient is non-irritating

微针仅引起轻微红斑，数小时内消退，表明透明质酸钠无显著皮肤刺激风险

Microneedles induced only slight erythema that disappeared within hours, indicating no significant skin irritation risk from sodium hyaluronate

该临床试验显示含0.1%透明质酸钠的人工泪液在白内障术后使用安全且耐受良好，未报告治疗相关不良事件，证实无眼刺激风险。

This clinical trial shows that artificial tears containing 0.1% sodium hyaluronate are safe and well tolerated after cataract surgery, with no treatment-related adverse events, confirming no eye irritation risk.

该文献报告5例患者因频繁使用高磷酸盐含量的透明质酸钠人工泪液导致角膜钙化，证实了该成分在特定条件下（高磷酸盐配方、频繁使用）存在眼刺激/角膜钙化风险。

This study reports 5 cases of corneal calcification due to frequent use of sodium hyaluronate artificial tears with high phosphate content, confirming eye irritation/corneal calcification risk under specific conditions (high phosphate formulation, frequent instillation).

该研究开发眼用热敏凝胶，加入透明质酸钠后未改善眼部滞留，但未提及眼刺激；透明质酸钠作为辅料，未评估其单独的眼刺激风险。

This study develops an ophthalmic thermosetting gel; adding sodium hyaluronate did not improve ocular retention, but no eye irritation was mentioned; sodium hyaluronate is used as an excipient, not evaluated for eye irritation.

文献证实含透明质酸钠的微针在动物皮肤刺激实验中未引起红斑或水肿，表明无皮肤刺激风险。

The study confirms that microneedles containing sodium hyaluronate caused no erythema or edema in animal skin irritation test, indicating no skin irritation risk.