苯氧乙醇

苯氧乙醇可激活TRPV1并增加其表达，从而引起皮肤刺激或敏感，但该研究主要关注提取物的抑制作用，间接证实了苯氧乙醇的刺激潜力。

Phenoxyethanol activates TRPV1 and increases its expression, causing skin irritation or sensitivity, but the study focuses on the inhibitory effect of the extract, indirectly confirming the irritation potential of phenoxyethanol.

在监管允许浓度下，苯氧乙醇在斑贴试验中引起轻微红斑，但在ROAT中可见反应，表明有轻微刺激潜力。

At regulatory acceptable concentrations, phenoxyethanol caused weak erythema in patch test and visible response in ROAT, indicating minor irritation potential.

在批准浓度下，苯氧乙醇在重建人表皮模型中未引起皮肤刺激，而其他一些杀菌剂有刺激。

Phenoxyethanol did not cause skin irritation in the reconstructed human epidermis model at approved concentrations, while some other biocides did.

在典型使用浓度下，含苯氧乙醇的配方未显示比不含防腐剂的配方更高的刺激评分，表明苯氧乙醇在正常使用条件下不增加皮肤刺激。

Formulas containing phenoxyethanol did not show higher irritation scores than those without preservatives at typical in-use concentrations, indicating phenoxyethanol does not contribute to skin irritation under normal use.

综述总结现有毒理学和皮肤病学数据，未发现2-苯氧乙醇在作为香料成分使用时具有显著的皮肤刺激风险。

The review summarizes available toxicology and dermatology data, finding no significant skin irritation risk for 2-phenoxyethanol as a fragrance ingredient.

苯氧乙醇在最低抑菌浓度下与其他防腐剂有相似的客观刺激潜力，但主观刺激因配方而异，与氯苯甘醚合用可增加刺激。

Phenoxyethanol has similar objective irritation potential at minimal inhibitory concentration, but subjective irritation varies with formulation and increases when combined with chlorphenesin.

体外实验显示苯氧乙醇在接近或低于人用批准浓度下可导致人睑板腺上皮细胞萎缩和死亡，支持眼刺激风险。

In vitro study shows phenoxyethanol causes atrophy and death of human meibomian gland epithelial cells at or below approved human-use concentrations, supporting eye irritation risk.

综述总结了现有毒理学和皮肤病学数据，包括眼刺激试验，但未明确证实苯氧乙醇存在眼刺激风险，且该文主要作为香料成分评估，并非专门针对眼刺激。

The review summarizes available toxicology and dermatology data including eye irritation tests, but does not confirm eye irritation risk for phenoxyethanol; it is a fragrance ingredient review, not specifically focused on eye irritation.

该研究仅调查产品中防腐剂的使用频率，未测试致敏性，但指出苯氧乙醇致敏力弱，是优选防腐剂，因此不证实其风险。

This study only surveyed the frequency of preservatives in products, did not test sensitization, but noted phenoxyethanol has weak sensitizing power and is a preferred preservative, thus not confirming its risk.

在69487例患者中，对苯氧乙醇的致敏反应罕见，表明其致敏风险低。

In 69487 patients, sensitization to phenoxyethanol was rare, indicating low sensitization risk.

在4308例患者中，甲基二溴戊二腈/苯氧乙醇阳性率显著下降，但仍为常见过敏原之一，证实其致敏风险。

In 4308 patients, methyldibromoglutaronitrile/phenoxyethanol positivity significantly decreased but remained a common allergen, confirming its sensitization risk.

在5085例患者中，甲基二溴戊二腈/苯氧乙醇阳性率为5.5%，证实其致敏风险。

In 5085 patients, methyldibromoglutaronitrile/phenoxyethanol had a positivity rate of 5.5%, confirming its sensitization risk.

在4454例患者中，甲基二溴戊二腈/苯氧乙醇阳性率为5.8%，表明苯氧乙醇作为防腐剂成分与过敏反应相关。

In 4454 patients, methyldibromoglutaronitrile/phenoxyethanol had a positivity rate of 5.8%, indicating phenoxyethanol as a component of the preservative is associated with allergic reactions.

在手部过敏性接触性皮炎患者中，甲基二溴戊二腈/苯氧乙醇2.0%和2.5%的阳性率分别为7.4%和6.3%，证实其致敏风险。

In patients with hand allergic contact dermatitis, methyldibromoglutaronitrile/phenoxyethanol 2.0% and 2.5% had positivity rates of 7.4% and 6.3%, respectively, confirming its sensitization risk.

在3120例患者中，甲基二溴戊二腈/苯氧乙醇阳性率为2%，证实其致敏性。

In 3120 patients, methyldibromoglutaronitrile/phenoxyethanol had a positivity rate of 2%, confirming its sensitizing potential.

在28349例患者中，甲基二溴戊二腈/苯氧乙醇在标准系列中致敏率约2%，在防腐剂系列中为2.2%，证实其致敏风险。

In 28349 patients, methyldibromoglutaronitrile/phenoxyethanol had a sensitization rate of about 2% in the standard series and 2.2% in the preservative series, confirming its sensitization risk.

综述提及生殖毒性数据，但未明确证实孕期风险，需结合原始研究评估。

The review mentions reproductive toxicity data but does not explicitly confirm pregnancy risk; needs evaluation of original studies.

经皮给予孕兔，在母体毒性剂量下未见胚胎毒性或致畸性，提示外用风险低。

Dermal administration to pregnant rabbits showed no embryotoxicity or teratogenicity even at maternally toxic doses, suggesting low risk for topical use.

该综述指出约6%人群对化妆品成分致敏，但苯氧乙醇的致敏风险未单独明确，且多数防腐剂安全边际>100，但未提供苯氧乙醇具体致敏数据。

The review notes that about 6% of the population is sensitized to cosmetic ingredients, but the sensitization risk of phenoxyethanol is not specifically clarified; most preservatives have MoS >100, but no specific sensitization data for phenoxyethanol is provided.