羟基积雪草甙

大鼠皮肤刺激研究表明该配方无刺激性

Skin irritation study in rats indicated the formulation was non-irritating

该文献研究羟基积雪草苷与隐丹参酮联用治疗痤疮，在斑马鱼模型中评估了发育毒性，但未发现羟基积雪草苷单独或联用导致发育毒性，且主要关注抗炎和抗菌作用，未提供孕期外用风险证据。

This study investigated madecassoside combined with cryptotanshinone for acne treatment. Zebrafish developmental toxicity was assessed, but no developmental toxicity was attributed to madecassoside alone or in combination. The focus was on anti-inflammatory and antibacterial effects, with no evidence of pregnancy risk from topical use.

该文献研究积雪草苷微针促进牙周软组织再生，未涉及经皮渗透安全风险，且体外显示促进成纤维细胞增殖，无刺激或致敏证据。

This study investigates madecassoside-loaded microneedles for periodontal regeneration, not percutaneous penetration safety; in vitro shows fibroblast proliferation, no irritation or sensitization evidence.

该文献研究积雪草苷传递体促进伤口愈合，未涉及经皮渗透安全风险，且体外细胞毒性显示细胞活力>80%，无刺激或致敏证据。

This study focuses on wound healing efficacy of madecassoside transfersomes, not on percutaneous penetration safety; in vitro cytotoxicity shows >80% viability, no irritation or sensitization evidence.