本页汇总 木脂素类 的 6 篇安全性公开文献，按毒性终点分区，逐条标注研究类型、物种、染毒途径与来源。以上均为各原研究/评估机构的结论，本平台不作再评价，也不构成对该成分的安全性判定。
提取物对角质形成细胞生长有积极作用，且添加提取物的沐浴凝胶配方可降低皮肤刺激性
The extract had a positive effect on keratinocyte growth, and the formulation containing the extract decreased skin irritation.
研究表明所有木质素对眼睛和皮肤无刺激性
The study demonstrated that all lignins are not harmful to eye and skin.
该综述提及千里光属植物含有木脂素，但主要毒性成分为吡咯里西啶生物碱，木脂素未单独讨论孕期风险。
This review mentions lignans as minor constituents of Senecio species, but the main toxic components are pyrrolizidine alkaloids; lignans are not specifically discussed for pregnancy risk.
小鼠卵母细胞暴露于鬼臼毒素（一种木脂素）后，细胞器分布和功能异常，影响减数分裂成熟，表明生殖毒性。但暴露途径为体外培养，非外用。
Exposure of mouse oocytes to podophyllotoxin (a lignan) caused organelle distribution and function abnormalities, affecting meiotic maturation, indicating reproductive toxicity. However, exposure was in vitro, not topical.
小鼠受精卵暴露于鬼臼毒素（一种木脂素）后，观察到纺锤体缺陷、DNA损伤和凋亡，表明早期胚胎发育毒性。但暴露途径为体外培养，非外用。
Exposure of mouse fertilized oocytes to podophyllotoxin (a lignan) caused spindle defects, DNA damage, and apoptosis, indicating early embryo developmental toxicity. However, exposure was in vitro, not topical.
该文为综述，讨论植物雌激素（包括木脂素）的雌激素效力评估方法，未提供木脂素孕期风险的直接证据。
This review discusses methods for evaluating estrogenic potency of phytoestrogens including lignans, but does not provide direct evidence of pregnancy risk from lignans.
毒理学实验记录来自标准化的毒性试验（如 OECD 导则试验），给出的是剂量/浓度层面的实验值；公开文献是研究者围绕化妆品实际使用场景发表的研究（本页 6 篇），结论均为原作者观点。两类证据并列呈现，本平台不做合并判定。
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