异亮氨酸

异亮氨酸仅作为弹性蛋白的氨基酸组成之一被提及，未单独测试其皮肤刺激性；弹性蛋白提取物在0.5 mg/mL以下无毒性，但未涉及异亮氨酸的皮肤刺激风险。

Isoleucine is only mentioned as an amino acid component of elastin, not individually tested for skin irritation; the elastin extract showed no toxicity below 0.5 mg/mL, but no data on isoleucine's skin irritation.

异亮氨酸作为阿昔洛韦前体药物的一部分，在5mM浓度下细胞毒性显著低于三氟胸腺嘧啶，且未提及眼刺激，故无风险证据。

Isoleucine as part of acyclovir prodrug showed significantly less cytotoxicity than trifluorothymidine at 5mM, and no ocular irritation was mentioned, thus no risk.

该文报道异亮氨酸缺乏导致角膜上皮脱落，间接表明异亮氨酸缺乏引起眼刺激，但非成分本身风险。

The article reports corneal deepithelialization due to isoleucine deficiency, indirectly indicating ocular irritation from deficiency, not from the ingredient itself.

该文献研究乳三肽（含异亮氨酸-脯氨酸-脯氨酸）的生殖毒性，最高剂量下未见不良效应，表明异亮氨酸三肽在口服暴露下无生殖毒性。

This study on lactotripeptide (containing isoleucine-proline-proline) shows no adverse effects on reproduction at highest doses tested, indicating no reproductive toxicity via oral exposure.

该文献讨论枫糖尿症（MSUD），指出孕期母体高亮氨酸可能致畸，但异亮氨酸是必需氨基酸，需补充；未直接研究异亮氨酸的孕期风险，而是作为疾病管理的一部分。

This review on MSUD mentions that elevated maternal leucine may be teratogenic, but isoleucine is an essential amino acid that needs supplementation; it does not directly study isoleucine's pregnancy risk.