羟基酪醇

28天人体应用未观察到皮肤刺激、红斑或毒性，Draize评分正常，表明羟基酪醇无皮肤刺激风险

No skin irritation, erythema, or toxicity observed after 28-day human application; normal Draize score indicates hydroxytyrosol has no skin irritation risk

大鼠体内试验显示羟基酪醇纳米颗粒未引起皮肤刺激，无不良反应水平高，表明无皮肤刺激风险

In vivo rat study showed no skin irritation from hydroxytyrosol nanoparticles; high no-observed-adverse-effect level indicates no skin irritation risk

动物实验显示该成分（羟基酪醇）未引起皮肤刺激或致敏反应，证实无致敏风险

Animal data showed that the ingredient (hydroxytyrosol) did not cause skin irritation or sensitization, confirming no sensitization risk

该研究评估羟基酪醇对双酚A诱导生殖毒性的保护作用，而非直接研究羟基酪醇本身的生殖毒性。羟基酪醇作为保护剂，未显示生殖毒性，反而减轻了BPA的毒性。

This study evaluates the protective effect of hydroxytyrosol against BPA-induced reproductive toxicity, not the reproductive toxicity of hydroxytyrosol itself. Hydroxytyrosol as a protective agent did not show reproductive toxicity but attenuated BPA toxicity.

在发育和生殖毒性研究中，HIDROX（含羟基酪醇）在高达2000 mg/kg/day剂量下未引起毒性，表明无生殖发育风险。

In developmental and reproductive toxicity studies, HIDROX (containing hydroxytyrosol) did not cause toxicity at levels up to 2000 mg/kg/day, indicating no reproductive/developmental risk.

在口服大鼠剂量范围生殖研究和发育毒性研究中，OPE（含羟基酪醇）在高达2000 mg/kg/day剂量下未对交配、生育、分娩或幼仔参数产生不良影响，且胎盘透过量极低，表明无生殖发育风险。

In oral rat dosage-range reproduction study and developmental toxicity study, OPE (containing hydroxytyrosol) did not adversely affect mating, fertility, delivery or litter parameters at up to 2000 mg/kg/day, and minimal levels crossed the placenta, indicating no reproductive/developmental risk.