羟基频哪酮视黄酸酯

15.3%患者出现轻中度局部副作用（干燥、脱屑、红斑、灼热），但无人因副作用停药，表明该组合有刺激性但可耐受

15.3% of patients experienced mild to moderate local side effects (dryness, peeling, erythema, burning), but no one discontinued due to side effects, indicating the combination is irritant but tolerable

斑马鱼胚胎发育毒性试验显示HPR微胶囊的致畸指数为1.9，低于阳性对照SymRenew™ HPR的3.1，但该试验为动物高剂量暴露，且暴露途径为水浴（类似系统暴露），外用化妆品剂量相关性需谨慎解读。

Zebrafish embryo developmental toxicity test showed teratogenicity index of HPR microcapsule was 1.9, lower than positive control SymRenew™ HPR (3.1), but this is animal high-dose exposure via water bath (systemic-like), relevance to topical cosmetic use needs caution.

人体斑贴试验和红细胞溶血试验均显示该纳米乳显著降低了HPR的刺激性，表明HPR在该递送系统中无刺激风险。

Human patch test and hemolysis assay demonstrated that the nanoemulsion significantly reduced HPR irritation, indicating no irritation risk for HPR in this delivery system.