本页汇总 和厚朴酚 的 4 篇安全性公开文献，按毒性终点分区，逐条标注研究类型、物种、染毒途径与来源。以上均为各原研究/评估机构的结论，本平台不作再评价，也不构成对该成分的安全性判定。
厚朴酚和和厚朴酚引起轻微但显著的角质形成细胞毒性和角质层破坏，但甲氧基化衍生物（尤其是二甲基和厚朴酚）在7天内无皮肤刺激，表明原成分有刺激风险但可通过结构修饰降低
Magnolol and honokiol induced slight but significant keratinocyte cytotoxicity and stratum corneum disruption, but methoxylated derivatives (especially dimethylhonokiol) showed no skin irritation for up to 7 days, indicating risk for parent compounds but modifiable
低剂量(0.15-0.21 μg/ml)抗氧化，高剂量(0.6 μg/ml)诱导氧化应激和凋亡，呈剂量依赖性；斑马鱼水浴暴露，人体外用相关性有限；作者建议孕妇慎用高剂量，但证据为动物和体外
Low doses (0.15-0.21 μg/ml) antioxidant, high dose (0.6 μg/ml) induced oxidative stress and apoptosis, dose-dependent; zebrafish water exposure, limited relevance to human topical use; authors recommend caution for high dose in pregnant women, but evidence from animal and in vitro
低剂量(0.15-0.30 μg/ml)有抗氧化作用，高剂量(0.6-0.9 μg/ml)引起发育毒性，呈剂量依赖性；暴露途径为水浴（类似外用），但斑马鱼模型与人体外用相关性有限
Low doses (0.15-0.30 μg/ml) showed antioxidant effects, high doses (0.6-0.9 μg/ml) caused developmental toxicity, dose-dependent; exposure via water (similar to topical), but relevance to human topical use is limited
静脉注射高剂量(2000 μg/kg/day)引起胎仔体长和尾长减少，但无畸形；NOAEL为600 μg/kg/day；暴露途径为静脉注射（系统性），非外用，且剂量远高于治疗剂量（250倍），人体外用化妆品剂量下风险需谨慎解读
High dose (2000 μg/kg/day) intravenous caused decreased fetal body length and tail length, but no malformations; NOAEL 600 μg/kg/day; exposure route is intravenous (systemic), not topical, and dose is 250 times therapeutic dose; risk at cosmetic topical doses should be interpreted cautiously
毒理学实验记录来自标准化的毒性试验（如 OECD 导则试验），给出的是剂量/浓度层面的实验值；公开文献是研究者围绕化妆品实际使用场景发表的研究（本页 4 篇），结论均为原作者观点。两类证据并列呈现，本平台不做合并判定。