Safflower fermentation solution did not cause vascular damage in CAM assay, indicating no eye irritation; fructose was only used as a fermentation substrate, not the tested ingredient.
Oral administration of isomaltulose up to 7 g/kg bw/day in rats induced no embryotoxic or teratogenic effects and no maternal toxicity, indicating no reproductive/developmental toxicity under tested conditions.
Animal studies show no reproductive or developmental toxicity at high doses of inulin-type fructans; clinical studies show good tolerance up to 20 g/day, indicating no pregnancy risk under tested conditions.