本页汇总 雌马酚 的 5 篇安全性公开文献，按毒性终点分区，逐条标注研究类型、物种、染毒途径与来源。以上均为各原研究/评估机构的结论，本平台不作再评价，也不构成对该成分的安全性判定。
大豆分离蛋白（含equol前体）喂养未引起睾丸雌激素样反应或生殖毒性，与雌二醇处理组不同。
Soy protein isolate (containing equol precursors) feeding did not elicit estrogenic response or reproductive toxicity in the testis, unlike estradiol treatment.
专家小组对大豆婴儿配方奶粉（含equol前体）的发育毒性表示“最小关注”，NTP结论为对婴儿发育不良效应风险极低。
The expert panel expressed 'minimal concern' for developmental toxicity of soy infant formula (containing equol precursors), and the NTP concluded there is minimal concern for adverse developmental effects in infants.
SE5-OH（含equol）在高达2000 mg/kg/day剂量下未观察到胚胎-胎儿发育效应，生殖毒性NOAEL为1000 mg/kg/day。
SE5-OH (containing equol) showed no embryo-fetal effects up to 2000 mg/kg/day, and the NOAEL for reproductive toxicity was 1000 mg/kg/day.
该研究显示，膳食大豆苷元（其代谢物为equol）在雌性大鼠中未显著影响生育力、后代性别比例或肛门生殖器距离，高剂量仅导致体重下降和孕酮水平降低，但未观察到生殖道病理变化。结论为大豆苷元在测试剂量下未引起显著的生殖毒性。
The study showed that dietary daidzein (metabolized to equol) did not significantly affect fertility, offspring sex ratio, or anogenital distances in female rats; high dose only reduced body weight and progesterone levels, but no reproductive tract pathology was observed. The conclusion was that daidzein did not cause significant reproductive toxicity at the tested doses.
equol在新生大鼠中仅减少子宫腺体数量，未增加子宫湿重或引起腔上皮肥大，作用不一致，既非典型雌激素也非抗雌激素作用。
Equol only decreased uterine gland number without increasing uterine wet weight or luminal epithelial hypertrophy, inconsistent with either estrogenic or antiestrogenic action.
毒理学实验记录来自标准化的毒性试验（如 OECD 导则试验），给出的是剂量/浓度层面的实验值；公开文献是研究者围绕化妆品实际使用场景发表的研究（本页 5 篇），结论均为原作者观点。两类证据并列呈现，本平台不做合并判定。
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