葡聚糖硫酸酯

该文献研究纳米粒的角膜渗透，未提及眼刺激，且纳米粒被内吞，无刺激描述。

The study investigates corneal penetration of nanoparticles, does not mention eye irritation, and nanoparticles are endocytosed without irritation description.

该文献报告6例患者因使用含硫酸葡聚糖的核黄素溶液进行CXL后出现持续性角膜上皮缺损、混浊和瘢痕，证实硫酸葡聚糖引起眼刺激和损伤。

This case series reports 6 patients who developed persistent corneal epithelial defects, haze, and scarring after CXL with riboflavin containing dextran sulfate, confirming eye irritation and damage caused by dextran sulfate.

该文献通过HET-CAM试验评估眼部耐受性，结果显示制剂与生理盐水相当，无刺激。

The study evaluated ocular tolerance via HET-CAM test, showing the formulation is comparable to saline with no irritation.

该文献研究纳米粒的制备和眼部递送，未提及眼刺激，且结论称纳米粒生物相容，无刺激证据。

The study focuses on nanoparticle preparation and ocular delivery, does not mention eye irritation, and concludes nanoparticles are biocompatible with no evidence of irritation.