肌酸

文献提及辛伐他汀引起过敏性接触性皮炎罕见，但肌酸作为成分并非研究焦点，且未提供肌酸致敏证据

The literature mentions rare allergic contact dermatitis to simvastatin, but creatine as an ingredient is not the focus, and no evidence of creatine sensitization is provided.

该研究评估了雷公藤甲素纳米颗粒的生殖毒性，结果显示其生殖毒性可忽略不计。肌酸仅作为血清指标（肌酸）被测量，并非研究成分。

This study evaluated reproductive toxicity of triptolide nanoparticles and found negligible reproductive toxicity. Creatine was measured only as a serum marker, not as the test ingredient.

该研究评估了大黄素的毒性，肌酸仅作为差异代谢物之一被检测，并非研究成分。未涉及肌酸本身的孕期风险。

This study assessed emodin toxicity; creatine was detected as one of the differential metabolites, not as the test ingredient. No pregnancy risk of creatine was studied.

该综述提出异维A酸通过凋亡机制导致致畸等不良反应，但仅涉及机理讨论，未直接研究肌酸（CREATINE）的孕期风险。肌酸仅作为不良反应中提及的释放物，非研究主题。

This review proposes that isotretinoin causes teratogenicity via apoptosis, but only discusses mechanism; creatine is mentioned only as a released substance in adverse effects, not as the subject of study.

该综述讨论了替比夫定的安全性，提及肌酸激酶升高，但未研究肌酸本身的孕期风险。替比夫定属于FDA妊娠B类，但肌酸非研究成分。

This review discusses safety of telbivudine, mentioning creatine kinase elevation, but does not study pregnancy risk of creatine itself. Telbivudine is FDA pregnancy category B, but creatine is not the test ingredient.

该研究比较了妊娠与非妊娠大鼠的血液学和生化指标，肌酸激酶作为指标之一被测量，但未研究肌酸本身的孕期风险。

This study compared hematology and clinical chemistry values between pregnant and non-pregnant rats; creatine kinase was measured as one parameter, but creatine itself was not studied for pregnancy risk.

该研究评估了西立伐他汀的生殖毒性，结果显示无胚胎毒性或致畸性。肌酸仅作为肌酸磷酸激酶指标提及，非研究成分。

This study evaluated reproductive toxicity of cerivastatin and found no embryotoxic or teratogenic effects. Creatine was mentioned only as creatine phosphokinase, not as the test ingredient.

该研究测量了脑内胆碱/肌酸比值，但肌酸仅作为波谱内标，非研究成分。未研究肌酸本身的孕期风险。

This study measured choline/creatine ratio in brain; creatine was used only as an internal reference in spectroscopy, not as the test ingredient. No pregnancy risk of creatine was studied.

该研究测量了胚胎神经外胚层中的磷酸肌酸和肌酸水平，但未研究肌酸本身的孕期风险。肌酸仅作为能量代谢指标，非研究成分。

This study measured phosphocreatine and creatine levels in embryonic neuroectoderm, but did not investigate the pregnancy risk of creatine itself. Creatine was only a metabolic marker.

该文献证实肌酸可经皮渗透并刺激胶原合成，改善皮肤老化，未提及任何安全风险，表明肌酸经皮渗透安全且有益。

This paper demonstrates that creatine penetrates skin and stimulates collagen synthesis, improving skin aging without any safety concerns, indicating dermal penetration is safe and beneficial.