本页汇总 鳕鱼肝油 的 6 篇安全性公开文献，按毒性终点分区，逐条标注研究类型、物种、染毒途径与来源。以上均为各原研究/评估机构的结论，本平台不作再评价，也不构成对该成分的安全性判定。
摘要指出鳕鱼肝油脂肪酸提取物在软膏基质中应用于人体皮肤时仅引起不显著的皮肤刺激，表明无显著刺激风险。
The abstract states that the fatty acid extract from cod-liver-oil caused insignificant skin irritation when applied to human skin, indicating no significant irritation risk.
文献报道了鱼肝油引起过敏性接触性皮炎的病例，斑贴试验阳性，证实其致敏风险。
The literature reports a case of allergic contact dermatitis to cod liver oil with positive patch test, confirming its sensitization risk.
该文献提及鳕鱼肝油因过量维生素A致畸性于1994年从产前诊所撤出，但未提供直接证据，且主要讨论维生素D缺乏。维生素A致畸性为系统性高剂量暴露，非化妆品外用途径。
The article mentions cod liver oil was withdrawn from antenatal clinics in 1994 due to excessive vitamin A teratogenicity, but provides no direct evidence, and mainly discusses vitamin D deficiency. Vitamin A teratogenicity is from systemic high-dose exposure, not topical cosmetic use.
该综述提及鳕鱼肝油因维生素A可能的致畸性而建议孕期避免，但未提供直接证据，且主要讨论omega-3脂肪酸的益处。维生素A致畸性为系统性暴露（口服高剂量），非化妆品外用途径。
The review mentions cod liver oil should be avoided in pregnancy due to possible teratogenicity of vitamin A, but provides no direct evidence, and mainly discusses benefits of omega-3s. Vitamin A teratogenicity is from systemic high-dose oral exposure, not topical cosmetic use.
该文献研究鳕鱼肝油/亚麻籽油混合物对苯妥英致畸性的影响，结果显示鳕鱼肝油/亚麻籽油组降低了苯妥英诱导的腭裂和胚胎蛋白共价结合，表明n-3脂肪酸可能抑制致畸性，而非鳕鱼肝油本身具有致畸风险。鳕鱼肝油作为膳食成分，未直接研究其孕期安全性，且暴露途径为膳食摄入，非化妆品外用。
This study investigates the effect of cod liver oil/linseed oil mixture on phenytoin teratogenicity, showing reduction in cleft palates and covalent binding, suggesting n-3 fatty acids may inhibit teratogenicity, not that cod liver oil itself poses a risk. Cod liver oil is a dietary component, not studied for topical cosmetic use.
该文献中鳕鱼肝油脂肪酸提取物在人体皮肤上应用时未引起明显刺激，表明无经皮渗透风险。
The cod-liver-oil fatty acid extract caused insignificant skin irritation when applied to human skin, indicating no risk for transdermal penetration.
毒理学实验记录来自标准化的毒性试验（如 OECD 导则试验），给出的是剂量/浓度层面的实验值；公开文献是研究者围绕化妆品实际使用场景发表的研究（本页 6 篇），结论均为原作者观点。两类证据并列呈现，本平台不做合并判定。
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