本页汇总 β-胡萝卜素 的 3 条毒理学研究记录 与 20 篇安全性公开文献，按毒性终点分区，逐条标注研究类型、物种、染毒途径与来源。以上均为各原研究/评估机构的结论，本平台不作再评价，也不构成对该成分的安全性判定。
该文献研究补骨脂素的皮肤致敏，β-胡萝卜素作为1O2清除剂被使用，结果显示其抑制了补骨脂素诱导的皮肤致敏，但未研究β-胡萝卜素本身的致敏性，因此不涉及该成分的致敏风险。
This study investigates psoralen skin sensitization; beta-carotene is used as a 1O2 scavenger and inhibits psoralen-induced sensitization, but does not address beta-carotene's own sensitization risk.
文献中β-胡萝卜素作为治疗EPP的药物被提及，五分之一患者报告有效，但未研究其光毒性风险，因此不相关。
Beta-carotene is mentioned as a treatment for EPP; one in five patients reported positive effect, but phototoxicity risk is not studied, thus irrelevant.
该文献研究EPP疾病本身，β-胡萝卜素作为治疗药物被提及，但未研究其光毒性风险，因此不相关。
This article studies EPP disease; beta-carotene is mentioned as a treatment, but does not investigate its phototoxicity risk, thus irrelevant.
综述指出β-胡萝卜素用于治疗EPP光敏性已超过30年，但未提供其本身光毒性的证据，因此不相关。
The review states beta-carotene has been used for EPP photosensitivity for >30 years, but provides no evidence of its own phototoxicity, thus irrelevant.
综述提及β-胡萝卜素大剂量用于治疗EPP以改善日光耐受性，但未研究其光毒性风险，因此不相关。
The review mentions high-dose beta-carotene for EPP to improve sunlight tolerance, but does not study its phototoxicity risk, thus irrelevant.
文献指出β-胡萝卜素在皮肤细胞培养中既有抗氧化也有促氧化作用，对正常皮肤的光保护作用不确定，存在潜在有害性，但未明确证实光毒性。
The article states beta-carotene has both antioxidant and prooxidant properties in skin cell culture; photoprotective effect in normal skin is uncertain, with potential harm, but phototoxicity not conclusively demonstrated.
综述提及β-胡萝卜素用于治疗EPP的光敏性，但未提供其本身光毒性的证据，且指出缺乏对照试验证实有效性，因此不直接支持光毒性风险。
The review mentions beta-carotene for treating EPP photosensitivity but provides no evidence of its own phototoxicity, noting lack of controlled trials; thus does not support phototoxicity risk.
β-胡萝卜素作为抗氧化剂预处理可减轻喹诺酮诱导的耳肿胀，表明其具有光保护作用而非光毒性，且β-胡萝卜素本身不是研究对象。
Beta-carotene pretreatment reduced quinolone-induced ear swelling, indicating photoprotection, not phototoxicity; beta-carotene is not the studied agent.
综述描述β-胡萝卜素用于治疗光敏性疾病，但未提供其本身光毒性的证据，因此不相关。
The review describes beta-carotene use for photosensitivity diseases but provides no evidence of its own phototoxicity, thus irrelevant.
该文献为综述，未提供β-胡萝卜素孕期风险的直接证据；β-胡萝卜素仅作为转基因作物的例子提及，无生殖毒性数据。
This review does not provide direct evidence on beta-carotene's pregnancy risk; beta-carotene is only mentioned as an example in GM crops, with no reproductive toxicity data.
氧化棕榈油（含β-胡萝卜素）在高剂量下显示生殖毒性，但新鲜棕榈油无此效应；β-胡萝卜素本身并非直接测试对象，且暴露途径为口服（饮食），非外用。
Oxidized palm oil (containing beta-carotene) showed reproductive toxicity at high doses, but fresh palm oil did not; beta-carotene itself was not directly tested, and exposure was oral (dietary), not topical.
类胡萝卜素通常被认为无毒；β-胡萝卜素干预研究在吸烟者中与肺癌增加相关，但未提及孕期风险。
Carotenoids are generally regarded as non-toxic; beta-carotene intervention studies in smokers were associated with increased lung cancer, but no mention of pregnancy risk.
多种动物高剂量β-胡萝卜素未观察到致畸性；人体流行病学未发现β-胡萝卜素致畸风险。
Multiple animal species exposed to high doses of beta-carotene showed no teratogenicity; human epidemiological studies found no teratogenic risk from beta-carotene.
β-胡萝卜素水平与HIV垂直传播无关；且维生素A补充剂在孕期有致畸性，但β-胡萝卜素未显示致畸风险。
Beta-carotene levels were not associated with vertical HIV transmission; vitamin A supplements are teratogenic during pregnancy, but beta-carotene has not shown teratogenic risk.
β-胡萝卜素毒性低，15-50 mg/天无副作用（除高剂量下高胡萝卜素血症）；无致畸或致癌证据。
Beta-carotene toxicity is low; 15-50 mg/day has no side effects except hypercarotenemia at high intakes; no teratogenic or carcinogenic evidence.
动物研究显示β-胡萝卜素无胚胎毒性或致畸性；人体高剂量（180 mg/天）用于光敏性疾病治疗多年未见不良妊娠结局。
Animal studies show no embryotoxicity or teratogenicity; human high doses (180 mg/day) used for photosensitivity for years without adverse pregnancy outcomes.
该文献为综述，讨论类胡萝卜素纳米药物的潜力，提及皮肤渗透但无原始实验数据，仅提供机理讨论，因此仅机理。
This is a review discussing the potential of carotenoid nanomedicines, mentioning skin penetration but without original experimental data, only mechanistic discussion, thus mechanism_only.
该文献研究β-胡萝卜素对紫外线过滤剂皮肤渗透的影响，发现β-胡萝卜素本身不渗透皮肤，而是减少紫外线过滤剂的皮肤滞留，未涉及β-胡萝卜素自身的经皮渗透风险，因此不相关。
This study investigates the effect of beta-carotene on skin penetration of UV-filters, finding that beta-carotene itself does not permeate skin but reduces retention of UV-filters; it does not address the percutaneous penetration risk of beta-carotene itself, thus irrelevant.
该文献主要研究维甲酸类的渗透和代谢，β-胡萝卜素仅作为内源性背景提及，未研究其经皮渗透，因此不相关。
This study focuses on penetration and metabolism of topical retinoids; beta-carotene is only mentioned as an endogenous substance, not studied for its own percutaneous penetration, thus irrelevant.
该文献研究β-胡萝卜素对脂氧合酶介导的脂质过氧化的抑制作用，未涉及β-胡萝卜素自身的经皮渗透，因此不相关。
This study investigates the inhibitory effect of beta-carotene on lipoxygenase-mediated lipid peroxidation, not its own percutaneous penetration, thus irrelevant.
以下终点（致癌性、遗传毒性、急性毒性等）属系统毒理学评估范畴，无对应的化妆品使用场景文献指标。
| 毒性终点 | 研究类型 | 物种 | 染毒途径 | 结果 | 年份 | 来源 |
|---|---|---|---|---|---|---|
| histopathology: neoplastic | 流行病学研究 | 人 | 经口 | LEL 20.0mg/day | 2012 | 美国 EPA ToxValDB 毒性值数据库｜Zenodo 公开数据集 |
| no effects | 临床试验 | 人 | 经口 | LEL 15.0mg/day | 2012 | 美国 EPA ToxValDB 毒性值数据库｜Zenodo 公开数据集 |
| 致死性 | 急性毒性 | 大鼠 | 经口 | LD50 2000.0mg/kg | 1983 | 美国 EPA ToxValDB 毒性值数据库｜echa.europa.eu |
本页汇总了 3 条来自公开评估报告与毒性值数据库的记录（含报告级结论与逐次实验记录），覆盖 3 项毒性终点。其中急性毒性一项的记录值为 LD50 2000 mg/kg（大鼠·经口）。以上均为原研究机构的实验结果，本平台只做汇总呈现，不作安全性结论；成分在具体配方中的安全性需按各国安全评估规范另行评估。
来自美国 CIR 专家组安全评估报告、美国 EPA ToxValDB 毒性值数据库、美国 NIH PubChem ChemIDplus 等公开数据源，每条记录都标注了研究类型、物种、染毒途径与出处报告，可逐条核对到来源。
毒理学实验记录来自标准化的毒性试验（如 OECD 导则试验），给出的是剂量/浓度层面的实验值；公开文献是研究者围绕化妆品实际使用场景发表的研究（本页 20 篇），结论均为原作者观点。两类证据并列呈现，本平台不做合并判定。