玉米黄质 × 抗皱

口服玉米黄质补充剂（单独或联合外用）在4周时显著减少总皱纹计数和细纹计数，12周时改善皱纹严重度。

Oral zeaxanthin supplement (alone or with topical) significantly reduced total wrinkle count and fine lines at week 4, and improved wrinkle severity at week 12.

玉米黄质显著减少UVB诱导的表皮厚度增加，抑制弹性纤维和胶原纤维变性，表明抗光老化（包括抗皱）效果。

Zeaxanthin significantly reduced UVB-induced epidermal thickening, inhibited degeneration of elastic and collagen fibers, indicating anti-photoaging (including anti-wrinkle) effect.

膳食补充叶黄素/玉米黄质显著减少UVB诱导的皮肤褶皱厚度和肥大细胞浸润，表明抗光老化（包括抗皱）效果。

Dietary lutein/zeaxanthin significantly reduced UVB-induced skin fold thickness and mast cell infiltration, indicating anti-photoaging (including anti-wrinkle) effect.

研究评估了叶黄素和玉米黄质联合口服/外用对皮肤参数的影响，但未单独分析玉米黄质对抗皱的效果，且主要终点为抗氧化保护而非抗皱。

The study evaluated combined lutein and zeaxanthin on skin parameters, but did not isolate zeaxanthin's effect on anti-wrinkle, and primary endpoints were antioxidant protection not anti-wrinkle.

研究使用含叶黄素、玉米黄质和迷迭香的复方制剂，无法单独归因于玉米黄质，且主要终点为皮肤水合而非抗皱。

Study used a formulation containing lutein, zeaxanthin, and rosemary; cannot attribute effect solely to zeaxanthin, and primary endpoint was skin hydration not anti-wrinkle.

研究显示玉米黄质抑制成纤维细胞迁移，涉及抗皱相关机制，但未直接测量皱纹或皮肤弹性等抗皱终点。

Study shows zeaxanthin inhibits fibroblast migration, a mechanism relevant to anti-wrinkle, but does not directly measure wrinkle or skin elasticity endpoints.

综述总结了类胡萝卜素（包括玉米黄质）抗光老化机制，如促进胶原和弹性蛋白生成，但未提供直接抗皱证据。

Review summarizes anti-photoaging mechanisms of carotenoids including zeaxanthin, such as promoting collagen and elastin production, but does not provide direct anti-wrinkle evidence.