In a double-blind randomized trial, PPP-4 cream improved crow's feet after 8 weeks, superior to placebo and AHP-3.
生物活性甘草酸离子液体自组装纳米胶束用于抗光老化信号肽的经皮递送增强。
结论解读 · 中文
动物光老化模型中，GAO/PAL-4-SM显著促进胶原和透明质酸再生，减少皱纹，提升弹性。
结论解读 · EN
In an animal photoaging model, GAO/PAL-4-SM significantly promoted collagen and hyaluronic acid regeneration, reduced wrinkles, and improved elasticity.
双功能化树枝状大分子用于刺激响应性释放活性成分至皮肤。
结论解读 · 中文
离体皮肤渗透实验显示纳米载体将PAL-4递送至真皮，人真皮成纤维细胞中联合维A醇显著增强胶原产生。
结论解读 · EN
Ex vivo skin penetration experiments showed nanocarriers delivered PAL-4 to the dermis; in human dermal fibroblasts, combination with retinol significantly enhanced collagen production.
PAL-4 alone had limited effects on fibroblast viability and ECM gene expression; synergistic effect was only observed when combined with i-PRF, insufficient evidence for standalone efficacy.
仅涉及作用机制1 篇
化妆品中多肽安全性评估框架。
结论解读 · 中文
仅通过序列同源性分析推测PAL-4与皮肤ECM蛋白同源，未进行功效验证。
结论解读 · EN
Only sequence homology analysis suggested PAL-4 is homologous to skin ECM proteins, without efficacy validation.